This phenomenon is not simply a side effect of the disease, but a direct biological consequence of the interaction of the disease with the body’s systems.
Biochemistry of Trousseau’s sign
For many years, doctors have recognized that unexplained blood clots can sometimes indicate underlying diseases. In the 19th century, the French physician Armand Trousseau observed that many patients suffered from recurrent blood clots long before being diagnosed. This medical phenomenon later became known as Trousseau’s syndrome.
Modern research has elucidated the mechanisms underlying this association. Advances in molecular biology have identified several biological “triggers” of pancreatic tumors that disrupt the blood clotting system.
Tissue factor (TF) overexpression
