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Recognizing these early warning signs can help detect the disease earlier.

The main culprit: deep vein thrombosis (DVT).

The strongest and most concerning link between leg swelling and pancreatic disease is the formation of blood clots, specifically a condition called deep vein thrombosis (DVT). This occurs when a clot forms inside a vein, usually in the leg, blocking normal blood flow. According to the Mayo Clinic, symptoms can include swelling, fever, pain, and sometimes a change in skin color in the affected limb.

Among the various serious pancreatic diseases, one stands out for its strong association with blood clot formation: pancreatic ductal adenocarcinoma (PDAC). This disease is so closely linked to clotting that doctors often refer to it as “procoagulant,” meaning it actively promotes blood thickening and clotting much more rapidly than normal.